![]() In ( B), we highlight that early on in the inflammatory response, immediate and early sequential pre-dominately pro-inflammatory mediators are released, which initiate and augment the acute-phase of the response (green lights). B, C) Represent the role that specific molecular mediators play in these events. Later during the response, mononuclear cells and macrophages accumulate and help prepare the tissue for resolution. Acute inflammation is characterized by the extravascular accumulation of neutrophils (PMN) and edema formation early in the response. 1) depicts the cellular and histological changes that occur in tissues following an inflammatory insult. Schematic depicting the cellular and molecular components of the inflammatory response and the requirements for resolution. Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation-associated diseases based on endogenous agonists of resolution. It is now evident that endogenous biochemical pathways activated during defense reactions can counter-regulate inflammation and promote resolution. The inflammatory response protects the body against infection and injury but can itself become dysregulated with deleterious consequences to the host. ![]() We concluded at the meeting that a consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti-inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today. ![]() Brain for the British Pharmacology Society. ![]() A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28, 2006, organized by D.W. ![]()
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